Non sedating ssris
The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications.All SSRIs are non-controlled prescription-only medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.Sexual dysfunction The SSRIs as a class produce a variety of sexual side effects, including anorgasmia, decreased libido, impotence, and delayed ejaculation.
Paroxetine and sertraline have been associated with slightly more cases of nausea.
Low levels of serotonin and norepinephrine have not been proven to cause depression but it is widely believed that elevation of these chemicals is associated with improvement in mood in depressed people.
All selective serotonin reuptake inhibitors have the same principal mechanism of action.
Each antidepressant produces approximately a 60% overall response rate (ie, at least a 50% reduction in symptoms as a result of treatment).
However, some differences in the SSRIs efficacy exist.